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CS-W001157 4
Total: USD 88.00

9-Boc-1-oxa-4,9-diazaspiro[5.5]undecane

  • CAS No. 930785-40-3

  • Cat. No. CS-W005674
  • Molecule weight256.34
  • Purity≥97%
  • MDL No.MFCD11227065

*For research and further manufacturing use only, not for direct human use.

9-Boc-1-oxa-4,9-diazaspiro[5.5]undecane|CS-W005674

Structure of 930785-40-3

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General Information

  • CAS No. 930785-40-3
  • Cat. No. CS-W005674
  • Purity ≥97%
  • MDL No. MFCD11227065
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₄N₂O₃
  • Molecular Weight 256.34
  • Synonym(s) tert-Butyl 1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate
  • SMILES O=C(N(CC1)CCC21CNCCO2)OC(C)(C)C

Description

9-Boc-1-oxa-4,9-diazaspiro[5.5]undecane is a sterically hindered, bench-stable spirocyclic amine derivative featuring a protected tertiary amine and an oxygen bridge. This structure enables selective coupling in peptide synthesis and complex molecule assembly, offering enhanced solubility and reduced side reactivity under standard conditions.

Application

9-Boc-1-oxa-4,9-diazaspiro[5.5]undecane serves as a stable, bench-accessible spirocyclic diamine building block for the synthesis of complex heterocyclic scaffolds. The Boc-protected amine and ether-functionalized spiro core enable orthogonal derivatization and facilitate purification. It functions effectively in amide coupling, reductive amination, and transition-metal-catalyzed cross-coupling reactions, offering high functional group tolerance and compatibility with standard synthetic workflows.

Synthesis

  • Route1

    References

    • Stocks, Michael J.; Alcaraz, Lilian; Bailey, Andrew; Bowers, Keith; Donald, David; Edwards, Helen; Hunt, Fraser; Kindon, Nicholas; Pairaudeau, Garry; Theaker, Jill; Warner, Daniel J. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7458 - 7461

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.8
  • LogP   1.3759
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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