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Structure of 945381-62-4
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7-Amino-5-fluoroindolin-2-one features a fused tricyclic core with strategic electron-withdrawing fluorine and nucleophilic amino substituents. This scaffold delivers enhanced metabolic stability and tunable polarity, enabling direct integration into bioactive small molecules. The para-amino group facilitates conjugation reactions, while the fluorine atom modulates electronic properties for targeted interactions in medicinal chemistry applications.
7-Amino-5-fluoroindolin-2-one serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated indoline scaffolds prevalent in kinase inhibitors and CNS-targeted therapeutics. Its amine functionality facilitates straightforward derivatization via amidation or reductive amination, while the fluoro substituent enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and compatibility with standard purification methods, making it well-suited for high-throughput screening campaigns and process-scale synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: