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CS-W001157 4
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1-Isopropyl-1H-pyrazol-4-amine

  • CAS No. 97421-16-4

  • Cat. No. CS-W020015
  • Purity≥95%
  • MDL No.MFCD08700622

*For research and further manufacturing use only, not for direct human use.

1-Isopropyl-1H-pyrazol-4-amine|CS-W020015

Structure of 97421-16-4

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General Information

  • CAS No. 97421-16-4
  • Cat. No. CS-W020015
  • Purity ≥95%
  • MDL No. MFCD08700622
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁N₃
  • Molecular Weight 125.17
  • Synonym(s) 4-AMINO-1-ISOPROPYL-1H-PYRAZOLE HCL
  • SMILES CC(N1N=CC(N)=C1)C

Description

1-Isopropyl-1H-pyrazol-4-amine features a pyrazole core functionalized with an isopropyl group at the 1-position and a primary amine at the 4-position, enabling versatile coupling reactions. This bench-stable scaffold integrates readily into pharmaceutical intermediates and bioactive molecule frameworks due to its favorable solubility and reactivity profile.

Application

1-Isopropyl-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyrazole-based scaffolds with enhanced solubility and metabolic stability. Its isopropyl group provides steric bulk and lipophilicity modulation, while the primary amine facilitates direct derivatization via acylation, alkylation, or coupling reactions. The compound exhibits good bench stability and ease of purification, making it suitable for high-throughput screening campaigns and API intermediate development.

Synthesis

  • Route1

    References

    • WO2006/40520 A1, ; Page/Page column 123-124 ; WO 2006/040520 A1
  • Route2
    • null|null
      75-30-9
    • ~%
    • In-stock
      1-Isopropyl-1H-pyrazol-4-amine|CS-W020015
      97421-16-4

    References

    • US2010/317680 A1, ; US 20100317680 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   1.0462
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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