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5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine

  • CAS No. 1180132-17-5

  • Cat. No. CS-M2088
  • Molecule weight220.32
  • Purity≥98%
  • MDL No.MFCD14706690

*For research and further manufacturing use only, not for direct human use.

5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine|CS-M2088

Structure of 1180132-17-5

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General Information

  • CAS No. 1180132-17-5
  • Cat. No. CS-M2088
  • Purity ≥98%
  • MDL No. MFCD14706690
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₀N₄
  • Molecular Weight 220.32
  • Synonym(s) 2-Pyridinamine, 5-[(4-ethyl-1-piperazinyl)methyl]-
  • SMILES NC1=NC=C(CN2CCN(CC)CC2)C=C1

Description

This pyridine-based amine features a strategically positioned ethylpiperazinylmethyl group, delivering enhanced solubility and tunable basicity. The conjugated system supports efficient metal coordination, while the piperazine moiety enables modular derivatization. Ideal for ligand design in catalysis and medicinal chemistry applications.

Application

5-((4-Ethylpiperazin-1-yl)methyl)pyridin-amine serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient construction of kinase inhibitors and CNS-targeted scaffolds. The pyridine nitrogen and primary amine facilitate metal-catalyzed coupling and derivatization, while the piperazine moiety enhances solubility and modulates pharmacokinetic properties. Bench-stable and readily purified by chromatography, this compound functions effectively in standard amide coupling, Suzuki-Miyaura, and reductive amination protocols.

Synthesis

  • Route1
    • 1-[(6-Bromopyridin-3-yl)methyl]-4-ethylpiperazine|CS-0007809
      1231930-25-8
    • ~%
    • In-stock
      5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine|CS-M2088
      1180132-17-5

    References

    • US2010/160340 A1, ; Page/Page column 9 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07,GHS08
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318-H373
Precautionary Statements : P260-P264-P270-P280-P301+P310-P305+P351+P338-P310-P314-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   45.39
  • LogP   0.8013
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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