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Structure of 385-02-4
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2-Fluoro-6-nitrobenzoic acid features a fluorine atom at the ortho position and a nitro group at the para position relative to the carboxylic acid, creating a strongly electron-deficient aromatic ring. This combination enhances reactivity in coupling reactions and improves solubility in polar solvents. The compound serves as a key intermediate in pharmaceutical synthesis, particularly for bioactive heterocycles and targeted drug candidates requiring halogenated or nitro-substituted scaffolds.
2-Fluoro-6-nitrobenzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of fluorinated aromatic systems with orthogonal nitro and carboxylic acid functionalities. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient derivatization via amide, ester, or amidation protocols. The electron-withdrawing nitro group enhances electrophilicity at the ortho position, supporting subsequent nucleophilic aromatic substitution or transition-metal-catalyzed functionalizations.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: