N-Fmoc-N-(2-phenylethyl)-glycine

CAS No. 540483-58-7
Cat. No. CS-0163398
Purity≥98%
MDL No.None

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N-Fmoc-N-(2-phenylethyl)-glycine|CS-0163398

Structure of 540483-58-7

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Description

N-Fmoc-N-(2-phenylethyl)-glycine features a protected glycine scaffold with orthogonal functionality, combining the Fmoc group for traceless deprotection and a benzylic amine handle. This bifunctional design enables seamless incorporation into peptide synthesis and conjugation workflows, offering high stability and efficient coupling under standard conditions.

Application

N-Fmoc-N-(2-phenylethyl)-glycine serves as a versatile dipeptide building block for solid-phase peptide synthesis and the construction of bioactive peptidomimetics. The Fmoc group enables orthogonal protection for primary amines, while the 2-phenylethyl side chain provides steric and electronic modulation. It exhibits excellent bench stability, facilitates efficient coupling reactions, and supports purification via standard chromatographic methods.

General Information

CAS No. 540483-58-7
Cat. No. CS-0163398
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₃NO₄
Molecular Weight 401.45
Synonym(s) N-α-(9-Fluorenylmethoxycarbonyl)-N-α-phenethylglycine
SMILES O=C(O)CN(C(OCC1C2=CC=CC=C2C3=CC=CC=C13)=O)CCC4=CC=CC=C4

Computational Chemistry Data

TPSA 66.84
LogP 4.5648
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 7

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science Amino Acids and their Derivatives Glycine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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N-Fmoc-N-(2-phenylethyl)-glycine

CAS No. 540483-58-7

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