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Structure of 875305-77-4
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4-Chloro-1H-indole-7-carboxylic acid integrates a chlorine substituent at the 4-position and a carboxylic acid group at the 7-position of the indole core. This configuration imparts enhanced electronic modulation and solubility, enabling direct use in coupling reactions and as a building block for bioactive heterocycles under standard conditions.
4-Chloro-1H-indole-7-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into indole-based pharmacophores. Its carboxylic acid functionality facilitates amide coupling, esterification, and metal-mediated transformations, while the 4-chloro substituent offers a handle for palladium-catalyzed cross-coupling reactions. The molecule exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for scalable synthesis of heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: