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3-Phenylcyclobutan-1-amine

  • CAS No. 90874-41-2

  • Cat. No. CS-0051224
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Phenylcyclobutan-1-amine|CS-0051224

Structure of 90874-41-2

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General Information

  • CAS No. 90874-41-2
  • Cat. No. CS-0051224
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃N
  • Molecular Weight 147.22
  • Synonym(s) 3-Phenylcyclobutanamine
  • SMILES NC1CC(C1)C1=CC=CC=C1

Description

3-Phenylcyclobutan-1-amine features a rigid cyclobutane scaffold bearing a primary amine and a phenyl substituent, enabling precise spatial orientation in molecular design. This structural motif delivers enhanced metabolic stability and favorable lipophilicity profiles, making it a valuable scaffold for medicinal chemistry campaigns targeting CNS-penetrant therapeutics and bioactive heterocycles.

Application

3-Phenylcyclobutan-1-amine serves as a valuable scaffold in medicinal chemistry, enabling the construction of bioactive heterocycles through standard functionalization. Its rigid cyclobutane core provides conformational constraint, while the primary amine facilitates derivatization via alkylation, acylation, or coupling reactions. The compound exhibits good bench stability and is compatible with common protecting group strategies, making it suitable for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.8913
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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