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Structure of 1006708-91-3
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(4R)-2-[2-[Bis[4-(trifluoromethyl)phenyl]phosphino]-5-(trifluoromethyl)phenyl]-4-tert-butyl-4,5-dihydrooxazole features a chiral oxazole scaffold with a sterically shielded tert-butyl group and a bulky bis(trifluoromethylphenyl)phosphine moiety. This configuration enhances stability and facilitates selective coordination in palladium-catalyzed cross-coupling reactions under standard conditions.
(4R)-2-[2-[Bis[4-(trifluoromethyl)phenyl]phosphino]-5-(trifluoromethyl)phenyl]-4-tert-butyl-4,5-dihydrooxazole serves as a robust, bench-stable phosphine ligand in palladium-catalyzed cross-coupling reactions. Its electron-rich, sterically encumbered structure enhances catalyst activity and stability, particularly in Suzuki-Miyaura and Buchwald-Hartwig couplings. The trifluoromethyl groups improve oxidative stability and solubility in organic media, while the dihydrooxazole ring provides a rigid scaffold that maintains ligand geometry under reaction conditions. Ideal for complex molecule synthesis requiring high functional group tolerance and reproducible yields.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: