2,6-Dichloropyridine-4-methanol

Name: 2,6-Dichloropyridine-4-methanol
Brand: ChemScene
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CAS No. 101990-69-6
Cat. No. CS-W021525
Purity≥97%
MDL No.MFCD00052638

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2,6-Dichloropyridine-4-methanol|CS-W021525

Structure of 101990-69-6

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Description

2,6-Dichloropyridine-4-methanol features a pyridine core functionalized with chloro groups at the 2 and 6 positions and a methanol handle at the 4 position. This configuration enables selective coupling reactions in synthetic pathways requiring electron-deficient heterocycles. The pendant hydroxyl group offers direct derivatization potential for further functionalization. The molecule exhibits enhanced stability under standard bench conditions and tolerates moisture better than analogous halogenated pyridines.

Application

2,6-Dichloropyridine-4-methanol serves as a versatile building block in medicinal chemistry, enabling efficient functionalization at the pyridine ring and methanol handle. Its dichloro substitution pattern facilitates directed metalation and nucleophilic aromatic substitution, while the benzylic alcohol group offers compatibility with standard protection and coupling strategies. The compound exhibits excellent bench stability and simplifies purification, making it well-suited for modular synthesis of heterocyclic scaffolds and API intermediates.

General Information

CAS No. 101990-69-6
Cat. No. CS-W021525
Purity ≥97%
MDL No. MFCD00052638
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅Cl₂NO
Molecular Weight 178.02
Synonym(s) 2,6-Dichloro-4-(hydroxymethyl)pyridine
SMILES ClC1=NC(=CC(=C1)CO)Cl

Computational Chemistry Data

TPSA 33.12
LogP 1.8807
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2,6-Dichloropyridine-4-methanol

CAS No. 101990-69-6

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