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Structure of 103440-54-6
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Methyl 5-iodo-2-methylbenzoate features a strategically positioned iodine atom at the para position relative to the ester group, enabling efficient cross-coupling reactions. The electron-deficient aromatic ring and methyl substituent enhance regioselectivity in palladium-catalyzed transformations. This bench-stable reagent integrates seamlessly into synthetic routes requiring halogenation for downstream functionalization.
Methyl 5-iodo-2-methylbenzoate serves as a versatile building block in cross-coupling chemistry, enabling palladium-catalyzed transformations such as Suzuki, Stille, and Negishi reactions. The iodide group provides high reactivity under standard conditions, while the methyl ester and methyl substituent offer stability and compatibility with common functional groups. Its bench-stable nature and predictable reactivity make it well-suited for the synthesis of substituted biaryls and complex heterocyclic scaffolds in medicinal chemistry and materials science.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: