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CS-W001157 4
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(2-Methylpyrimidin-5-yl)boronic acid

  • CAS No. 1034924-06-5

  • Cat. No. CS-0030061
  • Purity≥95%
  • MDL No.MFCD07375144

*For research and further manufacturing use only, not for direct human use.

(2-Methylpyrimidin-5-yl)boronic acid|CS-0030061

Structure of 1034924-06-5

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General Information

  • CAS No. 1034924-06-5
  • Cat. No. CS-0030061
  • Purity ≥95%
  • MDL No. MFCD07375144
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇BN₂O₂
  • Molecular Weight 137.93
  • Synonym(s) 2-METHYLPYRIMIDINE-5-BORONIC ACID
  • SMILES CC1=NC=C(B(O)O)C=N1

Description

This boronate moiety integrates readily into Suzuki-Miyaura cross-coupling reactions under standard conditions, delivering functionalized pyrimidine derivatives with high efficiency. The methyl substituent enhances solubility and stability, while the electron-deficient heterocycle ensures predictable reactivity.

Application

(2-Methylpyrimidin-5-yl)boronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its pyrimidine core provides enhanced stability and solubility compared to simpler heterocycles, while the boronic acid functionality facilitates reliable coupling with aryl, vinyl, and heteroaryl halides. The methyl substituent enhances electronic modulation and improves bench stability, making it well-suited for medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.24
  • LogP   -1.53518
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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