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CS-W001157 4
Total: USD 88.00

6-Bromo-3-fluoropicolinic acid

  • CAS No. 1052714-48-3

  • Cat. No. CS-0128563
  • Purity≥98%
  • MDL No.MFCD13185805
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-Bromo-3-fluoropicolinic acid|CS-0128563

Structure of 1052714-48-3

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Description

6-Bromo-3-fluoropicolinic acid features a strategically positioned bromine and fluorine substituent on the picolinic acid scaffold, enabling selective functionalization in pharmaceutical synthesis. The electron-withdrawing halogens enhance reactivity in cross-coupling processes while maintaining stability under standard conditions. This compound serves as a key building block for bioactive heterocycles and transition-metal-catalyzed transformations.

Application

6-Bromo-3-fluoropicolinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its dual halogenation (bromo at C6, fluoro at C3) enables selective cross-coupling reactions, particularly in palladium-catalyzed transformations. The carboxylic acid group facilitates direct derivatization or activation for amide bond formation, while the electron-withdrawing substituents enhance reactivity in nucleophilic aromatic substitution processes. This compound exhibits excellent bench stability and compatibility with standard purification techniques, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

General Information

  • CAS No. 1052714-48-3
  • Cat. No. CS-0128563
  • Purity ≥98%
  • MDL No. MFCD13185805
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃BrFNO₂
  • Molecular Weight 220.00
  • Synonym(s) 6-bromo-3-fluoro-2-pyridinecarboxylic acid
  • SMILES O=C(O)C1=NC(Br)=CC=C1F

Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.6814
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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