(3,5-Difluoropyridin-2-yl)methanol

Name: (3,5-Difluoropyridin-2-yl)methanol
Brand: ChemScene
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CAS No. 1065267-14-2
Cat. No. CS-0055645
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(3,5-Difluoropyridin-2-yl)methanol|CS-0055645

Structure of 1065267-14-2

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Description

(3,5-Difluoropyridin-2-yl)methanol features a pyridine core bearing fluorine substituents at the 3 and 5 positions, enhancing electron deficiency and enabling selective reactivity. The pendant hydroxymethyl group offers a handle for derivatization, while the molecule exhibits bench-stable behavior under standard conditions. This structure serves as a key building block in medicinal chemistry and materials synthesis.

Application

(3,5-Difluoropyridin-2-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient introduction of a polar, electron-deficient pyridylmethyl moiety. Its benzylic alcohol functionality facilitates direct oxidation to the carboxylic acid or conversion to esters and amides, while the difluoropyridine core supports diverse cross-coupling reactions. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, making it a practical choice for constructing bioactive heterocyclic scaffolds and functionalizing complex intermediates.

General Information

CAS No. 1065267-14-2
Cat. No. CS-0055645
Purity ≥95%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅F₂NO
Molecular Weight 145.11
Synonym(s) 3,5-Difluoropyridine-2-methanol
SMILES OCC1=NC=C(F)C=C1F

Computational Chemistry Data

TPSA 33.12
LogP 0.8521
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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(3,5-Difluoropyridin-2-yl)methanol

CAS No. 1065267-14-2

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