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Boc-NH-PEG4

  • CAS No. 106984-09-2

  • Cat. No. CS-0067500
  • Molecule weight293.36
  • Purity≥97%
  • MDL No.MFCD07779195

*For research and further manufacturing use only, not for direct human use.

Boc-NH-PEG4|CS-0067500

Structure of 106984-09-2

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General Information

  • CAS No. 106984-09-2
  • Cat. No. CS-0067500
  • Purity ≥97%
  • MDL No. MFCD07779195
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₇NO₆
  • Molecular Weight 293.36
  • Synonym(s) PROTAC Linker 12
  • SMILES O=C(OC(C)(C)C)NCCOCCOCCOCCO

Description

Boc-NH-PEG4 delivers a protected amine handle for modular conjugation, featuring a tert-butoxycarbonyl group flanked by a four-ethylene glycol spacer. This bench-stable linker enables efficient coupling in peptide synthesis and bioconjugation workflows under standard conditions.

Application

Boc-NH-PEG4 serves as a versatile bifunctional linker for conjugation and protection in peptide and oligonucleotide synthesis. The Boc group provides reliable N-terminal protection, while the PEG4 spacer enhances solubility and reduces aggregation. This compound facilitates efficient coupling reactions, enables straightforward deprotection under mild acidic conditions, and offers excellent stability during storage and handling—ideal for applications requiring precise functionalization and enhanced bioavailability.

Synthesis

  • Route1

    References

    • Lebeau, Luc; Oudet, Pierre; Mioskowski, Charles Helvetica Chimica Acta, 1991 , vol. 74, # 8 p. 1697 - 1706
  • Route2

    References

    • Ling, Frank H.; Lu, Victor; Svec, Frantisek; Frechet, Jean M. J. Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 1993 - 2002
  • Route3

    References

    • Kueny-Stotz, Marie; Mamlouk-Chaouachi, Hind; Felder-Flesch, Delphine Tetrahedron Letters, 2011 , vol. 52, # 22 p. 2906 - 2909

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   86.25
  • LogP   0.5532
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   11

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