tert-Butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate

Name: tert-Butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate
Brand: ChemScene
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CAS No. 1174020-42-8
Cat. No. CS-0048560
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate|CS-0048560

Structure of 1174020-42-8

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Description

tert-Butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate is a stereochemically defined piperidine derivative featuring a fluorine atom at the 3-position and a hydroxyl group at the 4-position. This configuration imparts enhanced metabolic stability and conformational rigidity, making it a valuable chiral building block for medicinal chemistry applications. The tert-butyl carbamate protecting group enables straightforward deprotection under mild acidic conditions, facilitating integration into complex molecular architectures.

Application

tert-Butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate serves as a stereochemically defined building block for fluorinated piperidine scaffolds prevalent in medicinal chemistry. The protected hydroxyl group enables selective transformations, while the C3-fluoro substituent imparts metabolic stability and modulates electronic properties. Its bench-stable nature and compatibility with standard coupling and reduction protocols facilitate efficient access to complex heterocyclic architectures.

General Information

CAS No. 1174020-42-8
Cat. No. CS-0048560
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₈FNO₃
Molecular Weight 219.25
Synonym(s) (3R,4S)-tert-butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate
SMILES CC(C)(C)OC(=O)N1CC[C@H](O)[C@H](F)C1

Computational Chemistry Data

TPSA 49.77
LogP 1.3262
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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tert-Butyl (3R,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate

CAS No. 1174020-42-8

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