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Structure of 1174309-16-0
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1-(Difluoromethyl)-1H-pyrazol-4-amine features a difluoromethyl group appended to a pyrazole scaffold, delivering enhanced metabolic stability and favorable lipophilicity. This electron-deficient heterocycle integrates readily into bioactive molecules, serving as a strategic isostere for carbonyl or methyl groups in medicinal chemistry applications.
1-(Difluoromethyl)-1H-pyrazol-4-amine serves as a versatile building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable difluoromethyl group at the pyrazole C1 position. Its amine functionality facilitates straightforward derivatization via coupling reactions, while the difluoromethyl moiety enhances lipophilicity and bioavailability. The compound exhibits good bench stability and is compatible with standard synthetic protocols, making it valuable for constructing diverse heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1760
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H314-H335
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Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501
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Lot numbers can be found on the outside label of a product: