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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-aminopiperazine-1-carboxylate

  • CAS No. 118753-66-5

  • Cat. No. CS-W001316
  • Molecule weight201.27
  • Purity≥95%
  • MDL No.MFCD08274502

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-aminopiperazine-1-carboxylate|CS-W001316

Structure of 118753-66-5

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General Information

  • CAS No. 118753-66-5
  • Cat. No. CS-W001316
  • Purity ≥95%
  • MDL No. MFCD08274502
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₉N₃O₂
  • Molecular Weight 201.27
  • Synonym(s) tert-Butyl 4-aMinopiperazin-1-carboxylate
  • SMILES NN1CCN(CC1)C(=O)OC(C)(C)C

Description

tert-Butyl 4-aminopiperazine-1-carboxylate delivers a protected piperazine scaffold with a primary amine at the 4-position, enabling direct functionalization in medicinal chemistry. This bench-stable derivative integrates readily into diverse synthetic sequences, offering enhanced solubility and compatibility in multi-step transformations.

Application

tert-Butyl 4-aminopiperazine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to piperazine-based scaffolds. The protected amine and carboxylate groups offer orthogonal reactivity, facilitating sequential functionalization. Its bench-stable nature and compatibility with standard coupling reactions make it ideal for modular synthesis of bioactive compounds, including kinase inhibitors and CNS-targeted molecules.

Synthesis

  • Route1
    • null|null
      877177-42-9
    • ~99%
    • In-stock
      tert-Butyl 4-aminopiperazine-1-carboxylate|CS-W001316
      118753-66-5

    References

    • TANABE SEIYAKU CO., LTD. Patent: WO2007/46550 A1, 2007 ; Location in patent: Page/Page column 120 ; WO 2007/046550 A1
  • Route2

    References

    • MACIELAG, Mark J.; Tennakoon, Manomi Patent: US2009/275594 A1, 2009 ; Location in patent: Page/Page column 19 ;
  • Route3
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • Piperazin-1-amine|CS-0098935
      30651-60-6
    • ~%
    • In-stock
      tert-Butyl 4-aminopiperazine-1-carboxylate|CS-W001316
      118753-66-5

    References

    • Nazare, Marc; Essrich, Melanie; Will, David William; Matter, Hans; Ritter, Kurt; Wehner, Volkmar Patent: US2003/199689 A1, 2003 ; Location in patent: Page/Page column 76 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   58.8
  • LogP   0.4128
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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