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Ethyl 6-(aminomethyl)nicotinate hydrochloride

  • CAS No. 1189434-55-6

  • Cat. No. CS-0102597
  • Purity≥97%
  • MDL No.MFCD09788628

*For research and further manufacturing use only, not for direct human use.

Ethyl 6-(aminomethyl)nicotinate hydrochloride|CS-0102597

Structure of 1189434-55-6

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General Information

  • CAS No. 1189434-55-6
  • Cat. No. CS-0102597
  • Purity ≥97%
  • MDL No. MFCD09788628
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃ClN₂O₂
  • Molecular Weight 216.66
  • Synonym(s) ethyl 6-(aminomethyl)-3-pyridinecarboxylate hydrochloride
  • SMILES O=C(C1=CC=C(CN)N=C1)OCC.[H]Cl

Description

Ethyl 6-(aminomethyl)nicotinate hydrochloride features a pyridine core with a strategically positioned aminomethyl group, enabling direct functionalization in synthetic workflows. The hydrochloride salt enhances solubility and stability under standard conditions, facilitating efficient incorporation into medicinal chemistry projects requiring nitrogen-rich scaffolds.

Application

Ethyl 6-(aminomethyl)nicotinate hydrochloride serves as a versatile building block for the synthesis of pyridine-based pharmaceutical intermediates. The pendant primary amine enables straightforward functionalization via amidation, alkylation, or reductive amination, while the ester group supports selective transformations. Its crystalline solid form offers excellent bench stability and ease of handling, facilitating purification by recrystallization or chromatography. This compound functions effectively in standard coupling protocols and heterocyclic scaffold elaboration, making it a practical choice for medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.21
  • LogP   1.1388
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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