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Structure of 1192813-64-1
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2-Chloro-5-(difluoromethoxy)pyrimidine features a difluoromethoxy group that enhances metabolic stability and membrane permeability. This electron-deficient pyrimidine serves as a key building block in medicinal chemistry, enabling direct incorporation into kinase inhibitors and antiviral agents through robust coupling reactions under standard conditions.
2-Chloro-5-(difluoromethoxy)pyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient Suzuki-Miyaura and Buchwald-Hartwig couplings due to its well-defined reactivity at the C2 position. The difluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the pyrimidine core provides a robust scaffold for kinase inhibitor development. Bench-stable and readily purified by flash chromatography, it functions reliably in multi-step synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: