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Structure of 1206980-54-2
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4-(Trifluoromethoxy)pyridin-2-amine features a trifluoromethoxy group at the 4-position and a primary amine at the 2-position of the pyridine ring, creating a uniquely electron-deficient heteroaryl scaffold. This configuration enables direct coupling in cross-coupling reactions and facilitates coordination in transition metal catalysis. The molecule exhibits enhanced solubility in organic solvents and stability under standard bench conditions.
4-(Trifluoromethoxy)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the pyridin-2-amine moiety provides a robust platform for further functionalization via Suzuki, Ullmann, or Buchwald–Hartwig couplings. The compound exhibits good bench stability and is readily purified by standard chromatographic methods, making it well-suited for scalable synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: