3-Bromo-5-fluoropyridin-4-amine

Name: 3-Bromo-5-fluoropyridin-4-amine
Brand: ChemScene
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CAS No. 1214326-89-2
Cat. No. CS-W003848
Purity≥97%
MDL No.MFCD13185327

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Bromo-5-fluoropyridin-4-amine|CS-W003848

Structure of 1214326-89-2

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General Information

CAS No. 1214326-89-2
Cat. No. CS-W003848
Purity ≥97%
MDL No. MFCD13185327
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄BrFN₂
Molecular Weight 191.00
Synonym(s) 4-Amino-3-bromo-5-fluoropyridine
SMILES NC1=C(Br)C=NC=C1F

Description

3-Bromo-5-fluoropyridin-4-amine features a pyridine core bearing bromo and fluoro substituents at meta positions relative to the amine, enabling selective cross-coupling and derivatization. The electron-deficient ring facilitates nucleophilic substitution, while the primary amine offers direct functional handles for conjugation. This scaffold delivers high reactivity under standard conditions, supporting rapid access to complex heterocycles in medicinal chemistry and materials science.

Application

3-Bromo-5-fluoropyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the fluorine enhances metabolic stability and modulates electronic properties. Its amine functionality supports direct derivatization or protection strategies, making it valuable for constructing heterocyclic scaffolds in API development. Bench-stable and readily purified by recrystallization, it integrates seamlessly into multi-step synthetic sequences.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 1.5654
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3-Bromo-5-fluoropyridin-4-amine

CAS No. 1214326-89-2

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