3,5-Difluoropyridin-4-amine

Name: 3,5-Difluoropyridin-4-amine
Brand: ChemScene
Availability: InStock
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CAS No. 159783-22-9
Cat. No. CS-W005200
Purity≥98%
MDL No.MFCD01862101

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 159783-22-9

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Description

3,5-Difluoropyridin-4-amine features a fluorinated pyridine core with strategically positioned electron-withdrawing substituents, enhancing its reactivity in cross-coupling and nucleophilic substitution processes. The amine group provides a versatile handle for derivatization, while the difluoro substitution imparts metabolic stability and improved membrane permeability. This compound serves as a key building block in medicinal chemistry and agrochemical synthesis.

Application

3,5-Difluoropyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 4-position via palladium-catalyzed cross-coupling reactions. Its difluoro substitution enhances metabolic stability and modulates electronic properties, while the primary amine facilitates derivatization through acylation, sulfonation, or reductive amination. Bench-stable and compatible with standard purification methods, it functions reliably in the construction of bioactive heterocycles and kinase inhibitor scaffolds.

General Information

CAS No. 159783-22-9
Cat. No. CS-W005200
Purity ≥98%
MDL No. MFCD01862101
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄F₂N₂
Molecular Weight 130.10
Synonym(s) 3,5-Difluoro-4-Pyridinamine
SMILES NC1=C(F)C=NC=C1F

Computational Chemistry Data

TPSA 38.91
LogP 0.942
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3,5-Difluoropyridin-4-amine

CAS No. 159783-22-9

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