2,3-Difluoropyridin-4-amine

Name: 2,3-Difluoropyridin-4-amine
Brand: ChemScene
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CAS No. 1227602-34-7
Cat. No. CS-0162501
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1227602-34-7
Cat. No. CS-0162501
Purity ≥97%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄F₂N₂
Molecular Weight 130.10
Synonym(s) 2,3-Difluoro-4-pyridinamine
SMILES NC1=C(F)C(F)=NC=C1

Description

2,3-Difluoropyridin-4-amine delivers a potent electron-deficient pyridine scaffold bearing two strategically positioned fluorine atoms. This configuration enhances metabolic stability and enables direct functionalization at the 4-amino site. The molecule integrates readily into kinase inhibitor scaffolds and other bioactive architectures, offering improved solubility and binding affinity in medicinal chemistry applications.

Application

2,3-Difluoropyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 4-position via nucleophilic substitution or Pd-catalyzed coupling. The difluoro substitution pattern enhances metabolic stability and modulates electronic properties, while the primary amine facilitates conjugation with carbonyl electrophiles or incorporation into heterocyclic scaffolds. Bench-stable and compatible with standard purification methods, it functions reliably in multi-step synthesis workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 0.942
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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2,3-Difluoropyridin-4-amine

CAS No. 1227602-34-7

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