(2S,5S)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate

Name: (2S,5S)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 1238951-37-5
Cat. No. CS-W021077
Purity≥96%
MDL No.MFCD08686668

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(2S,5S)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate|CS-W021077

Structure of 1238951-37-5

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Description

This chiral piperazine derivative features a tert-butyl ester group at the 1-position and methyl substituents at the 2- and 5-positions, enabling stereocontrolled synthesis. The sterically encumbered tert-butyl moiety enhances stability and facilitates selective deprotection under mild conditions. This scaffold integrates readily into complex molecular architectures requiring defined spatial orientation and robust functional group tolerance.

Application

(2S,5S)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate serves as a chiral piperazine scaffold for medicinal chemistry applications, offering defined stereochemistry and enhanced metabolic stability. The tert-butyl ester group provides bench stability and facilitates straightforward deprotection under mild acidic conditions. It functions as a versatile building block in the synthesis of bioactive molecules, particularly those requiring rigid, functionalized heterocyclic cores with predictable conformational behavior.

General Information

CAS No. 1238951-37-5
Cat. No. CS-W021077
Purity ≥96%
MDL No. MFCD08686668
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₂N₂O₂
Molecular Weight 214.31
Synonym(s) (2S,5S)-2,5-DIMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
SMILES C[C@H]1CN([C@@H](C)CN1)C(=O)OC(C)(C)C

Computational Chemistry Data

TPSA 41.57
LogP 1.6037
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(2S,5S)-tert-Butyl 2,5-dimethylpiperazine-1-carboxylate

CAS No. 1238951-37-5

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