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(R)-3-Methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butan-1-amine hydrochloride

  • CAS No. 1243174-57-3

  • Cat. No. CS-0136949
  • Purity≥95%
  • MDL No.MFCD26403994

*For research and further manufacturing use only, not for direct human use.

(R)-3-Methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butan-1-amine hydrochloride|CS-0136949

Structure of 1243174-57-3

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General Information

  • CAS No. 1243174-57-3
  • Cat. No. CS-0136949
  • Purity ≥95%
  • MDL No. MFCD26403994
  • Storage -20°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₅BClNO₂
  • Molecular Weight 249.59
  • Synonym(s) 1G; 5G; 10G; 25G; 500G
  • SMILES CC(C)C[C@@H](B1OC(C)(C(C)(O1)C)C)N.[H]Cl

Description

(R)-3-Methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butan-1-amine hydrochloride features a chiral boronate handle paired with a sterically defined amine side chain. This bench-stable reagent integrates seamlessly into Suzuki-Miyaura coupling workflows, enabling efficient C–C bond formation under mild conditions. The tetramethyl dioxaborolane moiety ensures high functional group tolerance and stability during storage and handling.

Application

(R)-3-Methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butan-1-amine hydrochloride serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. Its chiral tertiary amine functionality enables direct incorporation into bioactive scaffolds, while the tetramethylboronate group offers excellent functional group tolerance and compatibility with standard coupling conditions. The hydrochloride salt enhances solubility and handling, facilitating purification and integration into iterative synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   44.48
  • LogP   2.413
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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