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Structure of 1252597-70-8
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3-Chloro-5-iodopyrazin-2-amine features a pyrazine core bearing chlorine and iodine substituents at the 3- and 5-positions, respectively, enabling direct functionalization in cross-coupling reactions. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds, offering enhanced metabolic stability and tunable polarity. The iodide group serves as a high-reactivity handle for palladium-catalyzed transformations under standard conditions.
3-Chloro-5-iodopyrazin-2-amine serves as a versatile building block for the synthesis of functionalized pyrazine scaffolds in medicinal chemistry and agrochemical research. Its complementary halogen handles enable sequential cross-coupling reactions, including Pd-catalyzed Suzuki-Miyaura and Buchwald-Hartwig aminations, facilitating rapid diversification. The molecule exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: