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2-Amino-5-(trifluoromethyl)benzaldehyde

  • CAS No. 1288999-05-2

  • Cat. No. CS-0157670
  • Purity≥97%
  • MDL No.MFCD28359825

*For research and further manufacturing use only, not for direct human use.

2-Amino-5-(trifluoromethyl)benzaldehyde|CS-0157670

Structure of 1288999-05-2

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General Information

  • CAS No. 1288999-05-2
  • Cat. No. CS-0157670
  • Purity ≥97%
  • MDL No. MFCD28359825
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆F₃NO
  • Molecular Weight 189.13
  • Synonym(s) None
  • SMILES C1=C(C=C(C=O)C(=C1)N)C(F)(F)F

Description

2-Amino-5-(trifluoromethyl)benzaldehyde features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability, while the ortho-amino functionality enables direct coupling in heterocyclic synthesis. This bifunctional scaffold integrates readily into pharmaceutical intermediates and functional materials under standard conditions.

Application

2-Amino-5-(trifluoromethyl)benzaldehyde serves as a versatile building block in medicinal chemistry and materials science, enabling the synthesis of heterocyclic scaffolds via condensation, cyclization, and coupling reactions. Its electron-withdrawing trifluoromethyl group enhances metabolic stability and modulates electronic properties, while the aldehyde functionality facilitates imine formation and reductive amination. Bench-stable and compatible with diverse functional groups, it functions reliably in multi-step syntheses requiring high purity and reproducibility.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   2.1001
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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