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CS-W001157 4
Total: USD 88.00

5-Bromo-6-chloropyridin-3-ol

  • CAS No. 130115-85-4

  • Cat. No. CS-W018575
  • Purity≥95%
  • MDL No.MFCD09835248

*For research and further manufacturing use only, not for direct human use.

5-Bromo-6-chloropyridin-3-ol|CS-W018575

Structure of 130115-85-4

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General Information

  • CAS No. 130115-85-4
  • Cat. No. CS-W018575
  • Purity ≥95%
  • MDL No. MFCD09835248
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃BrClNO
  • Molecular Weight 208.44
  • Synonym(s) 2-Chloro-3-Bromo-5-Hydroxypyridine
  • SMILES OC1=CC(Br)=C(Cl)N=C1

Description

5-Bromo-6-chloropyridin-3-ol features a pyridinol core functionalized with bromo and chloro substituents at the 5- and 6-positions, respectively. This electron-deficient heterocycle integrates readily into cross-coupling reactions, serving as a robust building block for pharmaceutical intermediates and agrochemicals. The hydroxyl group enables direct derivatization or coordination in catalytic systems.

Application

5-Bromo-6-chloropyridin-3-ol serves as a versatile building block for the synthesis of heterocyclic scaffolds in medicinal chemistry and agrochemical research. Its orthogonal halogenation pattern enables selective cross-coupling reactions, while the phenolic hydroxyl group offers opportunities for derivatization or metal complexation. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic sequences and scale-up applications.

Synthesis

  • Route1
    • null|null
      130284-55-8
    • ~10%
    • In-stock
      5-Bromo-6-chloropyridin-3-ol|CS-W018575
      130115-85-4

    References

    • Koch; Schnatterer Synthesis, 1990 , # 6 p. 499 - 501
  • Route2

    References

    • Synthesis, , # 6 p. 499 - 501
  • Route3

    References

    • Synthesis, , # 6 p. 499 - 501

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   2.2031
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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