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Structure of 13073-27-3
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3-Chloro-2-hydroxybenzonitrile features a hydroxyl group ortho to a nitrile moiety on a chlorinated benzene ring, enabling direct functionalization in heterocyclic synthesis. The electron-withdrawing chlorine and polar nitrile facilitate coupling reactions under mild conditions. This scaffold offers enhanced solubility in organic media and stability during storage.
3-Chloro-2-hydroxybenzonitrile serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl and ortho-chloro positions. Its reactivity facilitates nucleophilic substitution, Suzuki-Miyaura coupling, and derivatization under mild conditions, with excellent bench stability and straightforward purification via recrystallization. Functions as a key intermediate for heterocyclic scaffolds and API precursors in pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: