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Structure of 131172-64-0
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4,5,6,7-Tetrahydro-1H-indole-2-carboxylic acid features a saturated indoline core with a carboxylic acid group at the 2-position, offering enhanced solubility and stability compared to aromatic analogs. This scaffold integrates readily into bioactive molecule design, particularly in CNS-targeted compounds and kinase inhibitors. The acidic proton enables salt formation and conjugation, while the hydrophobic indoline ring supports membrane permeability.
4,5,6,7-Tetrahydro-1H-indole-2-carboxylic acid serves as a versatile scaffold in medicinal chemistry, enabling the construction of biologically relevant heterocycles. Its carboxylic acid functionality facilitates amide coupling and esterification, while the saturated indoline core offers enhanced metabolic stability. The compound exhibits good bench stability and is compatible with standard purification methods, making it a practical building block for API development and combinatorial synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: