Lot numbers can be found on the outside label of a product:
Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate
-
CAS No. 133046-46-5
- Cat. No. CS-W006131
- Purity≥97%
- MDL No.MFCD10568298
*For research and further manufacturing use only, not for direct human use.
Structure of 133046-46-5
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 133046-46-5
- Cat. No. CS-W006131
- Purity ≥97%
- MDL No. MFCD10568298
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₆F₃NO₂S
- Molecular Weight 225.19
- Synonym(s) 4-Thiazolecarboxylic acid, 2-(trifluoromethyl)-, ethyl ester
- SMILES O=C(C1=CSC(C(F)(F)F)=N1)OCC
Description
Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate is a bench-stable, moisture-tolerant building block featuring a trifluoromethyl group that imparts strong electron-withdrawing character. This thiazole scaffold integrates readily into pharmaceutical intermediates and agrochemicals, where enhanced metabolic stability and lipophilicity are critical. The ester functionality enables straightforward derivatization under standard conditions.
Application
Ethyl 2-(trifluoromethyl)thiazole-4-carboxylate serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling efficient access to trifluoromethyl-substituted heterocycles. The molecule exhibits excellent bench stability and functional group tolerance, facilitating diverse transformations including nucleophilic substitution, palladium-catalyzed coupling reactions, and cyclization processes. Its electron-deficient thiazole core enhances reactivity in cross-coupling and conjugate addition protocols, making it a practical scaffold for the construction of bioactive molecules and advanced intermediates in API development.
Synthesis
-
Route1
-
In-stock
354-38-1 -
70-23-5 - ~41%
-
In-stock
133046-46-5
References
-
IDENIX PHARMACEUTICALS, INC.; PARSY, Christophe Claude; ALEXANDRE, Francois-Rene; LEROY, Frederic; CONVARD, Thierry; SURLERAUX, Dominique Patent: WO2011/17389 A1, 2011 ; Location in patent: Page/Page column 161-162 ; WO 2011/017389 A1
-
-
Route2
-
70-23-5
- ~20%
-
In-stock
133046-46-5
References
-
MERCK SHARP and DOHME LIMITED; NEUROGEN CORPORATION Patent: WO2006/122200 A1, 2006 ; Location in patent: Page/Page column 43-44 ; WO 2006/122200 A1
-
-
Route3
-
19172-47-5
-
In-stock
354-38-1
-
70-23-5
- ~32%
-
In-stock
133046-46-5
References
-
Kornacker, Michael G.; Mapelli, Claudio; Riexinger, Douglas James Patent: US2013/289238 A1, 2013 ; Location in patent: Page/Page column ;
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 39.19
- LogP 2.3386
- H_Acceptors 4
- H_Donors 0
- Rotatable_Bonds 2
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 133046-46-5 sigma133046-46-5 manufacturer133046-46-5 price133046-46-5 structure133046-46-5 SDSbuy 133046-46-5133046-46-5 supplier133046-46-5 uses133046-46-5 molecular weightprice of 133046-46-5133046-46-5 chemical name formula of 133046-46-5