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trans-4-[(Dimethylamino)methyl]cyclohexanamine dihydrochloride

  • CAS No. 1356954-01-2

  • Cat. No. CS-0202227
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

trans-4-[(Dimethylamino)methyl]cyclohexanamine dihydrochloride|CS-0202227

Structure of 1356954-01-2

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General Information

  • CAS No. 1356954-01-2
  • Cat. No. CS-0202227
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₂₂Cl₂N₂
  • Molecular Weight 229.19
  • Synonym(s) trans-4-[(dimethylamino)methyl]cyclohexan-1-amine dihydrochloride
  • SMILES N[C@H]1CC[C@H](CN(C)C)CC1.Cl.Cl

Description

trans-4-[(Dimethylamino)methyl]cyclohexanamine dihydrochloride is a bench-stable, moisture-tolerant amine derivative featuring a sterically hindered dimethylamino methyl group on a rigid cyclohexane scaffold. This configuration enhances solubility in protic solvents and facilitates efficient coupling reactions in synthetic workflows.

Application

trans-4-[(Dimethylamino)methyl]cyclohexanamine dihydrochloride serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient access to saturated heterocyclic scaffolds. The tertiary amine functionality offers excellent solubility and protonation stability, while the cyclohexyl framework provides conformational rigidity ideal for structure-activity studies. Its bench-stable form facilitates straightforward handling and purification, making it well-suited for multi-step synthesis and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   1.9091
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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