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2-[(tert-Butoxy)carbonyl]-2-azaspiro[3.5]nonane-7-carboxylic acid

  • CAS No. 1363381-18-3

  • Cat. No. CS-0052102
  • Purity≥97%
  • MDL No.MFCD22566156

*For research and further manufacturing use only, not for direct human use.

2-[(tert-Butoxy)carbonyl]-2-azaspiro[3.5]nonane-7-carboxylic acid|CS-0052102

Structure of 1363381-18-3

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General Information

  • CAS No. 1363381-18-3
  • Cat. No. CS-0052102
  • Purity ≥97%
  • MDL No. MFCD22566156
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₃NO₄
  • Molecular Weight 269.34
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CC2(C1)CCC(C(=O)O)CC2

Description

This spirocyclic scaffold features a protected amine and carboxylic acid moiety, enabling direct incorporation into peptide macrocycle synthesis. The tert-butyl carbamate group provides stability under standard conditions, while the rigid spiro architecture imparts conformational control.

Application

2-[(tert-Butoxy)carbonyl]-2-azaspiro[3.5]nonane-7-carboxylic acid serves as a robust spirocyclic building block for medicinal chemistry, enabling the construction of complex nitrogen-containing heterocycles. Its tert-butyl ester and carboxylic acid functionalities offer orthogonal reactivity, facilitating selective derivatization and incorporation into peptide-like scaffolds. The spirocyclic core provides conformational rigidity and enhanced metabolic stability, making it valuable in lead optimization campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.4983
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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