2,2,2-Trifluoro-1-phenylethan-1-amine hydrochloride

Name: 2,2,2-Trifluoro-1-phenylethan-1-amine hydrochloride
Brand: ChemScene
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CAS No. 13652-09-0
Cat. No. CS-0089740
Purity≥98%
MDL No.MFCD00971700

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,2,2-Trifluoro-1-phenylethan-1-amine hydrochloride|CS-0089740

Structure of 13652-09-0

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General Information

CAS No. 13652-09-0
Cat. No. CS-0089740
Purity ≥98%
MDL No. MFCD00971700
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₉ClF₃N
Molecular Weight 211.61
Synonym(s) 2,2,2-Trifluoro-1-phenylethanamine hydrochloride
SMILES NC(C1=CC=CC=C1)C(F)(F)F.[H]Cl

Description

2,2,2-Trifluoro-1-phenylethan-1-amine hydrochloride delivers a fluorinated amine scaffold with enhanced stability and solubility. This bench-stable salt features a trifluoromethyl group flanking a primary amine, enabling efficient incorporation into pharmaceutical intermediates. The hydrochloride form improves handling and crystallization behavior in synthetic workflows.

Application

2,2,2-Trifluoro-1-phenylethan-1-amine hydrochloride serves as a stable, bench-ready building block for fluorinated aromatic amines. Its trifluoromethyl group enhances metabolic stability and lipophilicity, making it valuable in medicinal chemistry workflows. The hydrochloride salt improves solubility and handling, enabling straightforward use in nucleophilic substitution, coupling reactions, and heterocycle synthesis. Functions reliably in standard amine transformations with good functional group tolerance.

Synthesis

Route1
- 119561-20-5
- ~97%
- In-stock
  
  13652-09-0
References
- Ono, Taizo; Kukhar, Valery P.; Soloshonok, Vadim A. Journal of Organic Chemistry, 1996 , vol. 61, # 19 p. 6563 - 6569
Route2
- In-stock
  
  434-45-7
- ~91%
- In-stock
  
  13652-09-0
References
- Gosselin, Francis; O'Shea, Paul D.; Roy, Stephanie; Reamer, Robert A.; Chen, Cheng-Yi; Volante, Ralph P. Organic Letters, 2005 , vol. 7, # 2 p. 355 - 358
Route3
- 119561-19-2
- ~%
- In-stock
  
  13652-09-0
References
- Journal of Organic Chemistry, , vol. 61, # 19 p. 6563 - 6569

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 26.02
LogP 2.6705
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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2,2,2-Trifluoro-1-phenylethan-1-amine hydrochloride

CAS No. 13652-09-0

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