6-Chloro-3-fluoropyridin-2(1H)-one

Name: 6-Chloro-3-fluoropyridin-2(1H)-one
Brand: ChemScene
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CAS No. 1369769-03-8
Cat. No. CS-0130965
Purity≥97%
MDL No.MFCD22547061

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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6-Chloro-3-fluoropyridin-2(1H)-one|CS-0130965

Structure of 1369769-03-8

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General Information

CAS No. 1369769-03-8
Cat. No. CS-0130965
Purity ≥97%
MDL No. MFCD22547061
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃ClFNO
Molecular Weight 147.53
Synonym(s) 6-chloro-3-fluoropyridin-2-ol
SMILES O=C1C(F)=CC=C(Cl)N1

Description

6-Chloro-3-fluoropyridin-2(1H)-one features a fused heterocyclic core with complementary halogen substituents enabling selective functionalization. The electron-deficient pyridinone scaffold facilitates nucleophilic substitution, while the fluorine and chlorine atoms provide orthogonal reactivity for downstream derivatization in medicinal chemistry and agrochemical synthesis.

Application

6-Chloro-3-fluoropyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its orthogonal reactivity facilitates nucleophilic substitution at the C6-chloro position and directs electrophilic functionalization at C4, while the 3-fluoro group enhances metabolic stability. The compound exhibits excellent bench stability and compatibility with standard coupling reactions, simplifying purification and integration into complex molecular architectures.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 32.86
LogP 1.1674
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-3-fluoropyridin-2(1H)-one

CAS No. 1369769-03-8

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