2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(benzyl)amino)acetic acid

Name: 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(benzyl)amino)acetic acid
Brand: ChemScene
Availability: InStock
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CAS No. 141743-13-7
Cat. No. CS-0205011
Purity≥98%
MDL No.MFCD04112686

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2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(benzyl)amino)acetic acid|CS-0205011

Structure of 141743-13-7

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General Information

CAS No. 141743-13-7
Cat. No. CS-0205011
Purity ≥98%
MDL No. MFCD04112686
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₁NO₄
Molecular Weight 387.43
Synonym(s) N-Fmoc-N-benzyl-glycine
SMILES O=C(O)CN(C(=O)OCC1C=2C=CC=CC2C=3C=CC=CC31)CC=4C=CC=CC4

Description

This fluorenylmethoxycarbonyl-protected amino acid derivative features a benzyl-substituted amine handle, enabling efficient solid-phase peptide synthesis. The fluoren-9-ylmethoxycarbonyl group ensures high-yield deprotection under mild conditions, while the benzyl moiety enhances solubility and stability during coupling steps.

Application

2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(benzyl)amino)acetic acid serves as a robust amino acid building block for peptide synthesis, combining the stability of Fmoc protection with benzyl-assisted solubility and orthogonal deprotection. Its structure enables efficient coupling reactions and facilitates purification via standard chromatographic methods, making it well-suited for iterative solid-phase synthesis workflows in medicinal chemistry and protein engineering.

Synthesis

Route1
- In-stock
  
  17136-36-6
- 28920-43-6
- ~%
- In-stock
  
  141743-13-7
References
- Weber, Dirk; Berger, Claudia; Eickelmann, Peter; Antel, Jochen; Kessler, Horst Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1918 - 1930
Route2
- In-stock
  
  6436-90-4
- ~%
- In-stock
  
  141743-13-7
References
- Chemistry - A European Journal, , vol. 4, # 8 p. 1570 - 1580
Route3
- 100-46-9
- ~%
- In-stock
  
  141743-13-7
References
- Chemistry - A European Journal, , vol. 4, # 8 p. 1570 - 1580

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 66.84
LogP 4.5223
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 6

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(benzyl)amino)acetic acid

CAS No. 141743-13-7

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