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Structure of 142167-36-0
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2-Hydroxy-5-trifluoromethylbenzonitrile features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability, while the phenolic hydroxyl enables direct participation in hydrogen bonding or derivatization. This combination delivers robust reactivity in electrophilic substitution and facilitates incorporation into bioactive scaffolds requiring polar yet lipophilic functionality.
2-Hydroxy-5-trifluoromethylbenzonitrile serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized heterocycles and bioactive scaffolds. Its ortho-hydroxyl and trifluoromethyl groups provide enhanced polarity and metabolic stability, while the nitrile moiety facilitates downstream transformations such as amidation or reduction. The compound exhibits good bench stability and is compatible with standard coupling protocols, facilitating integration into multi-step synthetic sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: