(1R,2R)-2-Fluorocyclopropan-1-amine hydrochloride

Name: (1R,2R)-2-Fluorocyclopropan-1-amine hydrochloride
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CAS No. 143062-85-5
Cat. No. CS-0143345
Purity≥95%
MDL No.None

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(1R,2R)-2-Fluorocyclopropan-1-amine hydrochloride|CS-0143345

Structure of 143062-85-5

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General Information

CAS No. 143062-85-5
Cat. No. CS-0143345
Purity ≥95%
MDL No. None
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃H₇ClFN
Molecular Weight 111.55
Synonym(s) None
SMILES N[C@H]1[C@H](F)C1.[H]Cl

Description

This fluorinated cyclopropane derivative features a chiral amine functionality stabilized by hydrochloride salt formation. The (1R,2R) stereochemistry imparts defined spatial orientation, enhancing selectivity in asymmetric synthesis. Bench-stable and moisture-tolerant, it serves as a key building block for bioactive molecules in medicinal chemistry and catalytic system design.

Application

(1R,2R)-2-Fluorocyclopropan-1-amine hydrochloride serves as a stereochemically defined building block for fluorinated cyclopropylamines, enabling access to bioactive scaffolds in medicinal chemistry. Its bench-stable hydrochloride salt facilitates handling and purification, while the strained cyclopropyl ring supports diverse transformations including nucleophilic substitution and cyclization reactions. Functions as a key intermediate in the synthesis of fluorinated analogs for CNS-targeted therapeutics and enzyme inhibitors.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 26.02
LogP 0.4773
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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(1R,2R)-2-Fluorocyclopropan-1-amine hydrochloride

CAS No. 143062-85-5

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