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Methyl 2-bromo-6-(trifluoromethyl)nicotinate

  • CAS No. 144740-56-7

  • Cat. No. CS-0463795
  • Purity≥97%
  • MDL No.MFCD12025861
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Methyl 2-bromo-6-(trifluoromethyl)nicotinate|CS-0463795

Structure of 144740-56-7

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Description

Methyl 2-bromo-6-(trifluoromethyl)nicotinate is a halogenated heterocyclic ester featuring a bromine atom at the 2-position and a trifluoromethyl group at the 6-position of the nicotinate ring. This combination imparts strong electron-withdrawing character and enhanced metabolic stability, enabling its use in cross-coupling reactions and as a building block for bioactive compounds. The methyl ester facilitates further functionalization under mild conditions.

Application

Methyl 2-bromo-6-(trifluoromethyl)nicotinate serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its bromo and ester functionalities. The trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient access to complex pyridine-based scaffolds.

General Information

  • CAS No. 144740-56-7
  • Cat. No. CS-0463795
  • Purity ≥97%
  • MDL No. MFCD12025861
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrF₃NO₂
  • Molecular Weight 284.03
  • Synonym(s) Methyl 2-bromo-6-(trifluoromethyl)pyridine-3-carboxylate, 2-Bromo-3-(methoxycarbonyl)-6-(trifluoromethyl)pyridine
  • SMILES COC(=O)C1=C(Br)N=C(C=C1)C(F)(F)F

Computational Chemistry Data

  • TPSA   39.19
  • LogP   2.6495
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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