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CS-W001157 4
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1-(2-Bromophenyl)cyclobutane-1-carboxylic acid

  • CAS No. 151157-44-7

  • Cat. No. CS-0101610
  • Purity≥98%
  • MDL No.MFCD11037044
  • HazMat Fee +

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    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-(2-Bromophenyl)cyclobutane-1-carboxylic acid|CS-0101610

Structure of 151157-44-7

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Description

This cyclobutane carboxylic acid derivative features a 2-bromophenyl group directly attached to the cyclobutane ring, delivering a rigid, electron-deficient aromatic moiety. The carboxylic acid functionality enables direct coupling or derivatization in synthetic workflows. The molecule exhibits enhanced stability and solubility under standard conditions, facilitating use in medicinal chemistry and materials synthesis.

Application

1-(2-Bromophenyl)cyclobutane-1-carboxylic acid serves as a versatile building block for medicinal chemistry and synthetic organic applications. The cyclobutane core provides conformational rigidity, while the ortho-bromophenyl moiety enables palladium-catalyzed cross-coupling reactions. Its carboxylic acid functionality facilitates derivatization via esterification, amide formation, or activation for peptide coupling. The compound exhibits good bench stability and is compatible with standard purification techniques, making it suitable for iterative synthesis and scaffold diversification in API development.

General Information

  • CAS No. 151157-44-7
  • Cat. No. CS-0101610
  • Purity ≥98%
  • MDL No. MFCD11037044
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁BrO₂
  • Molecular Weight 255.11
  • Synonym(s) 1-(2-BROMOPHENYL)CYCLOBUTANECARBOXYLIC ACID
  • SMILES O=C(C1(C2=CC=CC=C2Br)CCC1)O

Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.9554
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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