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N-Methyl-1-(pyridin-4-yl)methanamine

  • CAS No. 6971-44-4

  • Cat. No. CS-0150998
  • Molecule weight122.17
  • Purity≥98%
  • MDL No.MFCD00066937

*For research and further manufacturing use only, not for direct human use.

N-Methyl-1-(pyridin-4-yl)methanamine|CS-0150998

Structure of 6971-44-4

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General Information

  • CAS No. 6971-44-4
  • Cat. No. CS-0150998
  • Purity ≥98%
  • MDL No. MFCD00066937
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂
  • Molecular Weight 122.17
  • Synonym(s) N-methylpyridine-4-methylamine
  • SMILES CNCC1=CC=NC=C1

Description

N-Methyl-1-(pyridin-4-yl)methanamine features a pyridine ring conjugated to a methylene bridge and a tertiary methylamino group, delivering enhanced solubility and stability in polar solvents. This scaffold integrates readily into pharmaceutical intermediates and ligand designs, offering robust performance under standard bench conditions.

Application

N-Methyl-1-(pyridin-4-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-containing scaffolds via standard coupling reactions. Its tertiary amine functionality offers enhanced solubility and metabolic stability, while the pyridyl group provides orthogonal reactivity for further functionalization. The compound exhibits excellent bench stability and ease of purification, making it well-suited for high-throughput synthesis and process development workflows.

Synthesis

  • Route1

    References

    • WO2006/80954 A1, ; Page/Page column 80 ;
  • Route2
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      16273-55-5
    • ~%
    • In-stock
      N-Methyl-1-(pyridin-4-yl)methanamine|CS-0150998
      6971-44-4

    References

    • Journal of Medicinal Chemistry, , vol. 38, # 11 p. 1892 - 1903
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 38, # 11 p. 1892 - 1903

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   0.801
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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