Ethyl 2,6-dichloroisonicotinate

Name: Ethyl 2,6-dichloroisonicotinate
Brand: ChemScene
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CAS No. 1604-14-4
Cat. No. CS-0037453
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Ethyl 2,6-dichloroisonicotinate|CS-0037453

Structure of 1604-14-4

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Description

Ethyl 2,6-dichloroisonicotinate features a pyridine core with strategically positioned chlorine substituents at the 2- and 6-positions, enhancing electrophilic reactivity. This electron-deficient heterocycle integrates readily into synthetic sequences requiring halogen-directed functionalization. The ethyl ester group enables direct manipulation via hydrolysis or nucleophilic substitution. Bench-stable and moisture-tolerant, it serves as a robust building block for pharmaceutical intermediates and agrochemicals.

Application

Ethyl 2,6-dichloroisonicotinate serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted isonicotinates and heterocyclic scaffolds. Its dual chloro substituents enhance electrophilicity at the ring, facilitating nucleophilic aromatic substitution and transition-metal-catalyzed coupling reactions. The ester group provides a handle for selective transformations, while the compound exhibits good bench stability and ease of purification—key attributes for scalable synthesis and process development.

General Information

CAS No. 1604-14-4
Cat. No. CS-0037453
Purity ≥97%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇Cl₂NO₂
Molecular Weight 220.05
Synonym(s) Ethyl 2,6-dichloropyridine-4-carboxylate
SMILES CCOC(=O)C1=CC(=NC(=C1)Cl)Cl

Computational Chemistry Data

TPSA 39.19
LogP 2.5651
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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Ethyl 2,6-dichloroisonicotinate

CAS No. 1604-14-4

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