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CS-W001157 4
Total: USD 88.00

4-(Trifluoromethoxy)piperidine hydrochloride

  • CAS No. 1612172-50-5

  • Cat. No. CS-0057812
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(Trifluoromethoxy)piperidine hydrochloride|CS-0057812

Structure of 1612172-50-5

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General Information

  • CAS No. 1612172-50-5
  • Cat. No. CS-0057812
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁ClF₃NO
  • Molecular Weight 205.61
  • Synonym(s) 4-(Trifluoromethoxy)piperidine HCl
  • SMILES FC(F)(F)OC1CCNCC1.[H]Cl

Description

4-(Trifluoromethoxy)piperidine hydrochloride features a trifluoromethoxy group attached to a piperidine core, conferring enhanced lipophilicity and metabolic stability. This bench-stable salt form improves solubility and handling in synthetic workflows. The compound serves as a key building block in medicinal chemistry for developing CNS-targeted therapeutics and bioactive molecules requiring optimized membrane permeability.

Application

4-(Trifluoromethoxy)piperidine hydrochloride serves as a versatile building block in medicinal chemistry, enabling the introduction of a lipophilic trifluoromethoxy group at the piperidine nitrogen. The hydrochloride salt enhances solubility and stability, facilitating handling and purification. It participates reliably in nucleophilic substitution and reductive amination reactions, supporting the construction of diverse heterocyclic scaffolds relevant to CNS-targeted therapeutics and kinase inhibitors.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   1.6966
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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