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CS-W001157 4
Total: USD 88.00

5-Methyl-1H-indazole

  • CAS No. 1776-37-0

  • Cat. No. CS-W011089
  • Purity≥97%
  • MDL No.MFCD01606235

*For research and further manufacturing use only, not for direct human use.

5-Methyl-1H-indazole|CS-W011089

Structure of 1776-37-0

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General Information

  • CAS No. 1776-37-0
  • Cat. No. CS-W011089
  • Purity ≥97%
  • MDL No. MFCD01606235
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂
  • Molecular Weight None
  • Synonym(s) 5-Methyl Indazole
  • SMILES CC1=CC2=C(NN=C2)C=C1

Description

5-Methyl-1H-indazole is a heterocyclic compound featuring a methyl-substituted indazole core, offering enhanced lipophilicity and metabolic stability. This scaffold integrates readily into bioactive molecules, serving as a key pharmacophore in kinase inhibitors and CNS-targeted therapeutics. The methyl group improves membrane permeability while maintaining favorable electronic properties for target engagement.

Application

5-Methyl-1H-indazole serves as a versatile heterocyclic building block in medicinal chemistry, offering a stable, electron-rich scaffold with defined regiochemistry. Its methyl group enhances metabolic stability and provides a handle for further functionalization via directed ortho-metalation or cross-coupling reactions. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, facilitating integration into diverse API architectures and enabling efficient access to bioactive analogs.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.87132
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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