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Structure of 1799711-21-9
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dBET1 is a potent, selective degrader targeting BRD4, designed to induce ubiquitin-mediated proteolysis of the bromodomain protein. This molecule features a bifunctional architecture linking a BRD4-binding warhead to an E3 ligase recruiter, enabling efficient and targeted degradation under physiological conditions.
dBET1 serves as a potent, cell-permeable degrader of BRD4, enabling targeted protein degradation via the ubiquitin-proteasome system. Its structure incorporates a thalidomide-derived ligand for CRBN recruitment and a selective BRD4-binding moiety, facilitating efficient ternary complex formation. The compound exhibits high stability in physiological conditions and enables robust, dose-dependent degradation of BRD4 in cellular assays, making it a valuable tool for studying BET protein function and validating therapeutic target engagement in epigenetic research.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: