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Structure of 180283-66-3
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2-(Dimethylamino)pyrimidine-5-carboxylic acid features a pyrimidine core functionalized with a dimethylamino group at the 2-position and a carboxylic acid at the 5-position, enabling versatile conjugation and solubility enhancement. The electron-rich dimethylamino moiety enhances reactivity in coupling reactions, while the carboxylic acid provides a handle for amide formation or metal coordination. This structure supports integration into bioactive scaffolds and functional materials under standard conditions.
2-(Dimethylamino)pyrimidine-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of pyrimidine-based scaffolds with enhanced solubility and metabolic stability. The dimethylamino group provides strong electron-donating character, facilitating electrophilic substitution and transition metal-catalyzed coupling reactions. Its carboxylic acid functionality supports direct amidation or esterification, offering straightforward access to analogs for SAR studies. The compound exhibits good bench stability and is readily purified by recrystallization or chromatography, making it well-suited for high-throughput screening campaigns and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: