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Structure of 1827-27-6
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5-Amino-2-fluoropyridine is a fluorinated heterocyclic building block featuring an electron-rich pyridine core with complementary amino and fluorine substituents. This combination enables selective functionalization in medicinal chemistry, particularly for kinase inhibitors and bioactive scaffolds. The compound exhibits enhanced metabolic stability and favorable solubility profiles under standard conditions, facilitating integration into diverse synthetic sequences.
5-Amino-2-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. The amino group facilitates electrophilic substitution and palladium-catalyzed coupling reactions, while the ortho-fluorine supports directed metalation and nucleophilic aromatic substitution. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for modular synthesis of API intermediates and kinase inhibitor candidates.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H315-H318-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: