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Structure of 184763-07-3
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This fluorenylmethoxycarbonyl-protected azetidine derivative features a strained four-membered ring ideal for peptide synthesis. The Fmoc group enables orthogonal protection, while the azetidine core introduces conformational rigidity and enhanced metabolic stability in bioactive peptides. Designed for efficient coupling under standard conditions, this building block streamlines incorporation of constrained amino acid analogs into complex sequences.
1-(((9H-Fluoren-9-yl)methoxy)carbonyl)azetidine-2-carboxylic acid serves as a robust, bench-stable protected azetidine building block for peptide and medicinal chemistry applications. Its Fmoc group enables orthogonal deprotection under mild basic conditions, while the strained azetidine ring facilitates C–N bond formation in standard coupling reactions. The compound exhibits excellent functional group tolerance and simplifies purification due to high solubility and minimal side-product formation.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: