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Structure of 19230-50-3
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2-Iodo-5-nitrobenzoic acid features a carboxylic acid group flanked by iodine and nitro substituents at adjacent positions on the benzene ring. This electron-deficient aryl iodide enables direct coupling in transition-metal-catalyzed reactions, while the ortho-iodo and para-nitro groups enhance reactivity and stability under standard conditions.
2-Iodo-5-nitrobenzoic acid serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and functionalized heterocyclic scaffolds. The iodide group facilitates reliable Suzuki, Stille, and Negishi couplings, while the nitro and carboxylic acid functionalities provide orthogonal handles for further derivatization. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for iterative synthesis in medicinal chemistry and materials development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: